Estudio de la prevalencia de marcadores genéticos asociados a la lenta progresión del virus de la inmunodeficiencia humana tipo 1 en la población gallega / Prevalence study of the genetic markers associated with slow progression of human inmunodefiency virus type 1 in the Galician population (Northwest of Spain)

INTRODUCCIÓN: La deleción en el gen CCR5 (CCR5Δ32), el haplotipo HLA-B*27:05 y los polimorfismos rs2395029 y rs9264942 han sido relacionados con la lenta progresión de la infección por VIH-1. MÉTODOS: Analizamos a 408 pacientes en seguimiento. El análisis de la carga viral, linfocitosT CD4+ y demás variables clínicas fueron recogidas desde el diagnóstico. RESULTADOS: La prevalencia de los marcadores genéticos rs9264942, CCR5wt/Δ32, rs2395029 y alelo HLA-B*27:05 fue del 17,9, del 11,5, del 7,6 y del 6,4%, respectivamente. Del total de los pacientes, 354 fueron clasificados como progresores y 46 como no progresores a largo plazo (LTNP). Exceptuando el alelo HLA-B*27:05, los demás marcadores genéticos se relacionaron con la lenta progresión: CCR5wt/Δ32 (p = 0,011) y los SNP rs2395029 y rs9264942 (p < 0,0001), así como su asociación (p < 0,0001). CONCLUSIÓN: La frecuencia hallada del alelo HLA-B*57:01 fue mayor a lo publicado a nivel nacional. Con respecto al alelo HLA-B*27:05, no hemos podido relacionar su presencia con la lenta progresión

INTRODUCTION: The deletion in the CCR5 gene (CCR5Δ32), the HLA-B*27:05, and polymorphisms rs2395029 and rs9264942 have been associated with slower progression of HIV-1. METHODS: An analysis was performed on 408 patients on follow-up. The analysis of viral load, CD4+ Tlymphocytes and other clinical variables since the diagnosis of the infection were collected. RESULTS: The prevalence of the genetic markers rs9264942, CCR5wt/Δ32, rs2395029, HLA-B*27:05 was 17.9%, 11.5%, 7.6%, and 6.4%, respectively. Of all the patients, 354 were classified as progressors and 46 as long-term non-progressors (LTNPs). Except for the HLA-B*27:05 allele, other genetic markers were associated with slower progression: CCR5wt/Δ32 (P=.011) and SNPs rs2395029 and rs9264942 (P<.0001), as well as their association (P<.0001). CONCLUSION: The prevalence of the HLA-B*57:01 allele was higher than described nationally. No association could be found between the HLA-B*27:05 allele and the presence of slower disease progression

[Prevalence study of the genetic markers associated with slow progression of human inmunodefiency virus type 1 in the Galician population (Northwest of Spain)]. / Estudio de la prevalencia de marcadores genéticos asociados a la lenta progresión del virus de la inmunodeficiencia humana tipo 1 en la población gallega.

INTRODUCTION: The deletion in the CCR5 gene (CCR5Δ32), the HLA-B*27:05, and polymorphisms rs2395029 and rs9264942 have been associated with slower progression of HIV-1. METHODS: An analysis was performed on 408 patients on follow-up. The analysis of viral load, CD4+ Tlymphocytes and other clinical variables since the diagnosis of the infection were collected. RESULTS: The prevalence of the genetic markers rs9264942, CCR5wt/Δ32, rs2395029, HLA-B*27:05 was 17.9%, 11.5%, 7.6%, and 6.4%, respectively. Of all the patients, 354 were classified as progressors and 46 as long-term non-progressors (LTNPs). Except for the HLA-B*27:05 allele, other genetic markers were associated with slower progression: CCR5wt/Δ32 (P=.011) and SNPs rs2395029 and rs9264942 (P<.0001), as well as their association (P<.0001). CONCLUSION: The prevalence of the HLA-B*57:01 allele was higher than described nationally. No association could be found between the HLA-B*27:05 allele and the presence of slower disease progression.